Depnon 30mg Tab

Side Effects of Depnon 30mg Tab

Drowsiness; liver dysfunction and jaundice; gynaecomastia; convulsions; hypomania; hypotension; hypertension; coma; arthralgia; oedema; tachycardia; bradycardia; vomiting; dizziness and ataxia; anticholinergic effects. Potentially Fatal: Bone marrow suppression.

Drug Interactions

Blood levels decreased by phenobarbitone, carbamazepine and phenytoin. Monitor blood pressure with antihypertensive therapy. Mianserin may antagonise the action of antiepileptics by lowering the convulsive threshold. CNS depressant effects enhance by alcohol, sedatives. Potentially Fatal: Avoid MAOIs (and for 14 days after discontinuation).

Contraindications

lactation, porphyria.

Mechanism of Action

Mianserin is a structural analogue of serotonin (5-HT) with antagonistic effects at 5-HT2A, 5-HT2C and 5-HT3 receptors. Mianserin also blocks the inhibitory α2-receptors, thus leading to an increase in noradrenaline release. Absorption: Readily absorbed from the GIT (oral). Distribution: Widely distributed; crosses the blood-brain barrier; enters breast milk. Protein-binding: Extensive. Metabolism: Extensively hepatic by aromatic hydroxylation, N-oxidation, N-demethylation. Excretion: Urine (as metabolites), faeces (small amounts); 6-40 hrs (elimination half-life).

Special Precautions

Concurrent CNS depression; epilepsy; MAOIs withdrawal (at least 14 days after discontinuation); hepatic, renal or cardiac insufficiency; heart block or recent MI; angle-closure glaucoma; prostatic hyperplasia; diabetes mellitus; monitor blood count regularly.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.