Dermafine Cream

Uses of Dermafine Cream

Terbinafine is an anti fungal drug and is used in the treatment of fungal infection.

Side Effects of Dermafine Cream

Anorexia, nausea, abdominal pain, taste disturbances, diarrhoea, rash, urticaria. Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.

Drug Interactions

Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.

Contraindications

Hypersensitivity, active or chronic liver disease, lactation.

Mechanism of Action

Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast. Absorption: Absorbed well from the GI tract with 40% bioavailability (oral), minimal absorption (topical); peak plasma concentrations after 2 hr (oral). Distribution: Distributed into stratum corneum of the skin, nail plate, hair (concentrations higher than plasma) and breastmilk. Protein-binding: Extensive. Metabolism: Hepatic; converted to inactive metabolites. Excretion: Via urine; 17-36 hr (plasma elimination half-life); up to 400 hr (terminal elimination half-life) in prolonged therapy.

Special Precautions

Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.