Dipsalic Ointment 20gm

Side Effects of Dipsalic Ointment 20gm

Pruritus, irritation, folliculitis, maceration of skin, skin atrophy, hypertrichosis, acneiform eruptions, secondary infection, hypopigmentation, perioral dermatitis, allergic contact dermatitis, striae and miliaria.

Drug Interactions

NA

Contraindications

Viral skin infections e.g. vaccinia, varicella and herpes simplex. Tuberculosis, acne rosacea, fungal skin infections (moniliasis), perioral dermatitis and ulcerative conditions.

Mechanism of Action

Betamethasone dipropionate is a synthetic fluorinated corticosteroid. It is active topically and produces a rapid and sustained response in inflammatory dermatoses. It is also effective in less responsive conditions e.g. scalp psoriasis, chronic plaque psoriasis of the hands and feet. Salicylic acid has keratolytic action. It softens keratin, loosens cornified epithelium and desquamates the epidermis. It aids in the penetration of betamethasone. Absorption: Betamethasone dipropionate: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier. Salicylic acid: Exerts only local action after topical application. Distribution: Betamethasone dipropionate: Once absorbed systemically, it is bound to plasma proteins in varying extents. Metabolism: Betamethasone dipropionate: Once absorbed through the skin, it is metabolised mainly by the liver. Excretion: Betamethasone dipropionate: Once absorbed through the skin, it is excreted largely renally; may also be excreted via the bile.

Special Precautions

Not to be used in or near the eyes. Avoid contact with mucous membranes. Prolonged topical corticosteroid treatment may result in systemic corticosteroid effects; may also lead to formation of striae or atrophy of the skin or subcutaneous tissue. Absorption of corticosteroid through the skin is increased when used with occlusive dressings. Caution when used in patients with stasis dermatitis or other skin diseases with impaired blood circulation. Treatment should be re-evaluated on a 4-wkly basis. Pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.