Doxytin Tablets 10s

Side Effects of Doxytin Tablets 10s

Permanent staining of teeth; rash, superinfection; nausea, GI upsets, glossitis; dysphagia; photosensitivity, hypersensitivity; haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia. Potentially Fatal: Anaphylaxis.

Drug Interactions

Reduction in absorption and bioavailability when used with antacids, calcium, magnesium and iron. Chronic ethanol ingestion reduces serum concentrations. Metabolism increased by hepatic enzyme inducers such as rifampicin, phenytoin and carbamazepine. May reduce the efficacy of oral contraceptives. Potentially Fatal: Increases digoxin toxicity and effects of oral anticoagulants.

Contraindications

Children <8 yr; pregnancy, lactation; porphyria; hypersensitivity to tetracyclines; severe hepatic dysfunction; prolonged exposure to sunlight or tanning equipment.

Mechanism of Action

Doxycycline binds to 30S and 50S ribosomal subunits thus causing alterations on the cytoplasmic membrane of susceptible organisms. Absorption: Readily and almost completely absorbed from the GI tract (oral); peak plasma concentrations after 2 hr. Absorption not significantly affected by food. Distribution: Lipid-soluble; into body tissues and fluids. Protein-binding: 80-95%. Metabolism: Inactivated in the liver. Excretion: Via urine (40%, may be increased if urine is alkaline); 12-24 hr (elimination half-life).

Special Precautions

Impaired hepatic function; history or predisposition to oral candidiasis. Should be taken with at least a glass of water in an upright position to reduce the risk of oesophageal injury.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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