Duzine 0.5mg Tablet 10s

Uses of Duzine 0.5mg Tablet 10s

Dutasteride helps in Treating symptoms of benign prostatic hyperplasia (BPH) or enlargement of the prostate gland. It also helps to reduce the risk of urinary blockage and the need for surgery to treat BPH.

Side Effects of Duzine 0.5mg Tablet 10s

Impotence; decreased libido; ejaculation disorders; breast tenderness and enlargement.

Drug Interactions

Concurrent use with CYP3A4 inhibitors such as diltiazem and verapamil may increase serum levels of dutasteride.

Contraindications

Severe liver impairment; pregnant women, children, adolescent.

Mechanism of Action

Dutasteride has antiandrogenic properties. It inhibits 5α-reductase, thus preventing the conversion of testosterone to 5α-dihydrotestosterone which is the main androgen involved in causing prostate enlargement. Absorption: Absorbed from the GI tract, reaching peak serum concentration in 1-3 hr. Bioavailability: About 60%. Distribution: Highly bound to plasma proteins. Metabolism: Metabolised by CYP3A4 and CYP3A5. Excretion: Mainly excreted as metabolites in faeces. Elimination half-life: About 3-5 wk.

Special Precautions

Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling dutasteride capsules. Advisable to exclude other causes of benign prostatic hypertrophy (e.g. prostate cancer, infection) before initiating therapy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.