Fadine-20 Tab

Side Effects of Fadine-20 Tab

Headache, dizziness, constipation, diarrhoea, nausea, rash, GI discomfort, fatigue, gynaecomastia, impotence.

Drug Interactions

Reduced absorption of famotidine with antacids hence admin should be separated by 2 hr. Reduced absorption of ketoconazole and itraconazole. Avoid ethanol (may cause gastric mucosal irritation).

Contraindications

Hypersensitivity; lactation.

Mechanism of Action

Famotidine competitively blocks histamine H2-receptors thus reducing basal, nocturnal and stimulated gastric acid secretion. Pepsin secretion is reduced resulting in decreased peptic activity. It effectively heals duodenal and gastric ulcers and prevents recurrence. Absorption: Readily but incompletely absorbed from the GI tract; peak plasma concentrations after 1-3 hr (oral). Distribution: Enters the breast milk. Protein-binding: 15-20%. Metabolism: Hepatic (small proportion); converted to famotidine S-oxide. Excretion: Urine (as unchanged) within 24 hr; 2.5-3.5 hr (elimination half-life).

Special Precautions

Impaired renal function, liver cirrhosis; pregnancy. Possibility of malignancy should be considered prior to initiating treatment as drug may mask symptoms and delay diagnosis. No safety and efficacy data is available for children <1 yr.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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This content is for educational purposes only. Please consult your doctor before use.