Facid Injection

Side Effects of Facid Injection

Headache, dizziness, constipation, diarrhoea, nausea, rash, GI discomfort, fatigue, gynaecomastia, impotence.

Drug Interactions

Reduced absorption of famotidine with antacids hence admin should be separated by 2 hr. Reduced absorption of ketoconazole and itraconazole. Avoid ethanol (may cause gastric mucosal irritation).

Contraindications

Hypersensitivity; lactation.

Mechanism of Action

Famotidine competitively blocks histamine H2-receptors thus reducing basal, nocturnal and stimulated gastric acid secretion. Pepsin secretion is reduced resulting in decreased peptic activity. It effectively heals duodenal and gastric ulcers and prevents recurrence. Absorption: Readily but incompletely absorbed from the GI tract; peak plasma concentrations after 1-3 hr (oral). Distribution: Enters the breast milk. Protein-binding: 15-20%. Metabolism: Hepatic (small proportion); converted to famotidine S-oxide. Excretion: Urine (as unchanged) within 24 hr; 2.5-3.5 hr (elimination half-life).

Special Precautions

Impaired renal function, liver cirrhosis; pregnancy. Possibility of malignancy should be considered prior to initiating treatment as drug may mask symptoms and delay diagnosis. No safety and efficacy data is available for children <1 yr.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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