Gemcite-1000mg Inj.
MRP: ₹8,290.00
Packaging
1 x 1 INJECTION
Composition
Gemcitabine 1000mg
Company
Eli Lilly
Substitutes for Gemcite-1000mg Inj.
| Medicine | Company | Price | You Save |
|---|---|---|---|
| Gemtaz 1000mg Injection | Sun Pharma | ₹4,722.00 | Save ₹3,568.00 |
| Biogem 1000mg Inj. | United Biotech | ₹5,300.00 | Save ₹2,990.00 |
| Gemspera 1000mg Inj. | Indoco Remedies | ₹5,500.00 | Save ₹2,790.00 |
| Oncogem 1000 mg Injection | Cipla | ₹5,795.00 | Save ₹2,495.00 |
| Gemtrust 1000mg Inj. | Panacea Biotec | ₹6,000.00 | Save ₹2,290.00 |
| Abingem 1000mg Inj | Miracauls | ₹6,200.00 | Save ₹2,090.00 |
| Celgem-1000mg Inj. | Alkem Labs | ₹6,354.00 | Save ₹1,936.00 |
| Cytogem 1000 mg Injection | Dr. Reddy | ₹6,800.00 | Save ₹1,490.00 |
Side Effects of Gemcite-1000mg Inj.
Bone marrow suppression as manifested by leukopenia, thrombocytopenia, anaemia and myelosuppression. Mild GI effects; rashes; renal impairment, pulmonary toxicity, influenza-like symptoms; interstitial pneumonia, pulmonary oedema. Proteinuria, haematuria and haemolytic uraemic syndrome. Elevation of serum transaminase. Potentially Fatal: Oesophagitis and pneumonitis when given with radical radiotherapy to the thorax.
Drug Interactions
May increase the anticoagulant effect of warfarin when used together.
Contraindications
Concurrent radical radiotherapy; pregnancy, lactation; hypersensitivity.
Mechanism of Action
Gemcitabine is a synthetic pyrimidine nucleoside and cytarabine analogue which is metabolised intracellularly to active diphosphate and triphosphate nucleosides. It inhibits DNA synthesis by inhibiting DNA polymerase and ribonucleotide reductase. It also induces apoptosis and is primarily active against cells in the S-phase, but may also arrest cells at the G1-S border. Metabolism: Rapidly cleared from the blood and metabolised by cytidine deaminase in the liver, kidney, blood, and other tissues after IV admin. Excretion: Mainly excreted in the urine. Half life ranges from 42-94 minutes.
Special Precautions
Children, hepatic and renal impairment. May impair ability to drive or operate machinery. Discontinue on 1st sign of microangiopathic haemolytic anaemia. Prolonged infusion time (>60 minutes) and more frequent than wkly dosing may increase toxicity. Monitor CBC before every dose. Increased risk of haemolytic uraemic syndrome and/or thrombocytcpenic purpura which may lead to irreversible renal failure.
How to Use
Take orally with food and water, as directed by your physician.
How to Store
Keep in a cool, dry place away from sunlight and moisture.
Safety Concerns
- Alcohol: Avoid during treatment.
- Breastfeeding: Not recommended.
- Pregnancy: Contraindicated.
- Liver/Kidney: Use with caution.
Content Disclaimer
This content is for educational purposes only. Please consult your doctor before use.
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Written by: SastiMedic Medical Team
Reviewed by: Registered Pharmacist