Hivus LR Tablet 60s

Side Effects of Hivus LR Tablet 60s

Diarrhoea, vomiting, headache, asthenia, abdominal pain, and nausea ; elevations in liver enzymes, total cholesterol and triglycerides.

Drug Interactions

Co-administration with drugs primarily metabolized by CYP3A (e.g. dihydropyridine Ca channel blockers, HMG-CoA reductase inhibitors, immunosuppressants and sildenafil) may result in increased plasma concentrations of the other drugs that could increase or prolong their therapeutic and adverse effects. Potentially Fatal: Drugs that should not be used concurrently: rifampicin, ergot derivatives, cisapride, HMG Co-A inhibitors, pimozide, and sedatives (midazolam, triazolam).

Contraindications

Hypersensitivity. Avoid concomitant use with ergot derivatives (dihydroergotamine, ergonovine, ergotamine, methylergonovine), cisapride, pimozide, and sedatives (midazolam, triazolam).

Mechanism of Action

Lopinavir inhibits HIV protease, causing the enzyme incapable of processing the polyprotein precursor. This leads to the production of non-infectious and immature HIV particles. Ritonavir, a selectively competitive reversible inhibitor of HIV protease, interferes with the formation of essential proteins and enzymes. After which, the formation of immature and non-infectious viruses follows. It also interferes with the production of infectious HIV and limits further infectious spread of the virus.

Special Precautions

Pancreatitis, hepatic impairment, haemophilia. Pregnancy, lactation, elderly, child <6 mth.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.