Lopez 1mg Tab

Uses of Lopez 1mg Tab

Lorazepam is used as a short-term (2-4 weeks) therapy for anxiety, or sleeping difficulties due to anxiety. It may also be used to relax a patient before surgery including dental surgery.

Side Effects of Lopez 1mg Tab

Drowsiness, headache, dizziness, confusion; blurred vision; nausea; weakness; unsteadiness. Potentially Fatal: Respiratory depression.

Drug Interactions

Potentiation of CNS depression produced by alcohol; general anaesthetics; narcotic analgesics; TCAs; MAOIs; phenothiazines; antipsychotics; barbiturates; scopolamine.

Contraindications

Severe hepatic impairment; respiratory depression; acute narrow-angle glaucoma; pregnancy and lactation.

Mechanism of Action

Lorazepam is a short acting benzodiazepine. Lorazepam enhances the inhibitory effect of GABA on neuronal excitability by modulating GABAA receptors. Onset: Hypnosis: 20-30 min (IM); sedation: 5-20 min (IV); anticonvulsant: 5 min (IV), 30-60 min (oral). Duration: 6-8 hr. Absorption: Readily absorbed (oral, IM); peak plasma concentrations after 2 hr. Distribution: Crosses the placenta and blood-brain barrier; enters breast milk. Protein-binding: 85%. Metabolism: Hepatic; converted to inactive metabolites. Excretion: Urine and faeces; 10-20 hr (elimination half-life).

Special Precautions

Hepatic and renal dysfunction; pulmonary insufficiency; myasthenia gravis; may impair ability to drive or operate machinery; elderly or debilitated patients.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.