Losium-25 Tab

Uses of Losium-25 Tab

Antihypertensive. It is used in the management of high blood pressure.

Side Effects of Losium-25 Tab

Headache, dizziness, back pain, myalgia, respiratory tract disorders, asthenia/fatigue, first dose hypotension, rash, angioedema, neutropenia, GI disturbances, transient elevation of liver enzymes, impaired renal function, taste disturbances and hyperkalaemia.

Drug Interactions

Hypotensive effect of losartan potentiated by diuretics and other antihypertensives. Risk of hyperkalaemia increases with concomitant ACE inhibitors, ciclosporin, potassium-sparing diuretics and K supplements. Hypotensive effect may be antagonised and increased risk of renal impairment when used with NSAIDs. Potentially Fatal: Risk of lithium toxicity with losartan use.

Contraindications

Pregnancy, lactation; children with CrCl <30 ml/min/1.73m2.

Mechanism of Action

Losartan is an angiotensin II receptor antagonist. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors. Absorption: Readily absorbed from GI tract with peak plasma concentrations of losartan after around 1 hr and its active metabolite after 3-4 hr. Distribution: 98% plasma protein bound. Metabolism: Hepatic metabolism principally by isoenzymes CYP3A4 and 2C9. Excretion: Excreted in faeces and urine as metabolites and unchanged drug. Terminal elimination half life of 2 hr (losartan) and 6-9 hr (active metabolite).

Special Precautions

Volume-depleted patients including patients on diuretics and salt restriction; renal artery stenosis; elderly; renal or hepatic impairment. Monitor serum-potassium concentration.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.