Methergin 0.2mg Inj.

Side Effects of Methergin 0.2mg Inj.

Headache, dizziness, hallucinations; tinnitus; nausea, vomiting, foul taste, diarrhoea; hypertension, temporary chest pain, palpitations, bradycardia; nasal congestion, dyspnoea; diaphoresis; thrombophlebitis; haematuria; water intoxication; leg cramps; allergic reactions. Potentially Fatal: Shock.

Drug Interactions

Possible increase in serum levels and risk of severe vasoconstrictive effects with potent CYP3A4 inhibitors (e.g. erythromycin, troleandomycin, clarithromycin, ritonavir, indinavir, nelfinavir, delavirdine, ketoconazole, itraconazole, voriconazole) and less potent CYP3A4 inhibitors (e.g. saquinavir, nefazodone, fluconazole, fluoxetine, fluvoxamine, zileuton, clotrimazole).

Contraindications

Hypertension, eclamptic or previously hypertensive patients, heart disease, venoatrial shunts, mitral valve stenosis, obliterative vascular disease. Do not use in cases of threatened spontaneous abortion. Pregnancy.

Mechanism of Action

Methylergometrine is an ergot alkaloid, which directly stimulates contractions of uterine and vascular smooth muscle. Onset: 5-15 min (oral); 2-5 min (IM); immediate (IV). Duration: ≥3 hr (oral/IM); 45 min (IV). Absorption: Rapidly absorbed (oral; IM). Distribution: Mainly distributed into plasma and extracellular fluid; rapidly distributed into tissues. Enters the breast milk. Metabolism: Hepatic: Undergoes first-pass metabolism. Excretion: Mainly via faeces; via urine (small amounts as unchanged drug); 2-3 hr (elimination half-life).

Special Precautions

Captivation of the placenta may occur if given during the 2nd or 3rd stage of labour prior to delivery of the placenta; use in this situation should only be done by a qualified personnel. Avoid prolonged use. Caution in patients with sepsis, hepatic or renal impairment. Lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.