Monit OD Tablet

Side Effects of Monit OD Tablet

Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence. Potentially Fatal: Severe hypotension and cardiac failure.

Drug Interactions

Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension. Potentially Fatal: Significant hypotension may occur when used with phosphodiesterase-5 inhibitors.

Contraindications

Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage

Mechanism of Action

Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload). Onset: 20 min (oral as conventional tab). Duration: 8-10 hr (oral as conventional tab). Absorption: Readily absorbed from the GIT (oral); peak plasma concentrations after 1 hr. Distribution: Widely distributed: Smooth muscle cells of the blood vessels. Metabolism: Converted to inactive metabolites including isosorbide and isosorbide glucuronide. Excretion: Via urine (2% as unchanged); 4-5 hr (elimination half-life).

Special Precautions

Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.