Numelin 75mg Capsule 10s

Uses of Numelin 75mg Capsule 10s

Pregabalin and Methylcobalamin combination is used various nerve pain conditions like fibromyalgia or diabetic neuropathy .

Side Effects of Numelin 75mg Capsule 10s

Dizziness, drowsiness, visual disturbance (including blurred vision, diplopia), ataxia, dysarthria, tremor, lethargy, memory impairment, euphoria, wt gain, constipation, dry mouth, peripheral edema, depression, confusion, agitation, hallucinations, myoclonus, hypoaesthesia, hyperaesthesia, tachycardia, excessive salivation, sweating, flushing, rash, muscle cramp, myalgia, arthralgia, urinary incontinence, dysuria, thrombocytopenia, neutropenia, 1st ° heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis.

Drug Interactions

Concurrent use with oxycodone, lorazepam and ethanol may increase the CNS effects.

Contraindications

Hypersensitivity. Pregnancy, lactation. Driving or working with machines, or do other dangerous activities.

Mechanism of Action

Pregabalin is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P. Absorption: Rapidly absorbed after oral doses. Peak plasma concentrations are achieved within 1.5 hr. Distribution: Not bound to plasma proteins. Metabolism: Negligible metabolism. Excretion: About 98% excreted unchanged in urine. Elimination half life: about 6.3 hr.

Special Precautions

Discontinue treatment if patients develop severe angioedema. Withdraw treatment gradually over at least 1 wk. May cause peripheral oedema. Regular vision check is recommended. May decrease platelet count and prolong PR interval.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.