Palip XR 6mg Tablet 10s

Uses of Palip XR 6mg Tablet 10s

Paliperidone is an atypical antipsychotic medicine and is used in the treatment of schizophrenia in adults and adolescents

Side Effects of Palip XR 6mg Tablet 10s

Tachycardia, headache, somnolence, orthostatic hypotension, AV block, bundle branch block, akathisia, parkinsonism, dizziness, wt gain, hyperkinesia, dose-dependent dyskinesia, tremor, weakness, abdominal pain, dry mouth, hypersalivation, vomiting.

Drug Interactions

Increased risk of antipsychotic-related extrapyramidal symptoms when used with central acetylcholinesterase inhibitors. May reduce the therapeutic effect of anti-Parkinson's agents (dopamine agonist). Serum levels may be reduced by carbamazepine. Concurrent use may increase toxicity of other CNS depressants. Serum levels may be increased by itraconazole. Lithium may increase neurotoxic effects of paliperidone.

Contraindications

Hypersensitivity to paliperidone or risperidone.

Mechanism of Action

Paliperidone is a benzisoxazole atypical antipsychotic which is a main active metabolite of risperidone. It is reported to be an antagonist at dopamine D2, serotonin (5-HT2), adrenergic (a1 and a2), and histamine (H1) receptors. It is used for the acute and maintenance treatment of schizophrenia. Absorption: Bioavailability: About 28%. Distribution: Protein binding: 74%. Metabolism: Hepatic via CYP2D6 and 3A4. Excretion: Elimination half-life: 23 hr; prolonged in renal impairm

Special Precautions

Not to be used in elderly patients with dementia-related psychosis due to increased risk of mortality. Avoid use in patients with congenital long-QT syndrome or history of cardiac arrhythmia. May cause oesophageal dysmotility and aspiration; caution in patients at risk of pneumonia. Increased risk of tardive dyskinesia in the elderly, especially women. Monitor glucose control in patients with or with risk factors for diabetes or other disorders of glucose regulation. Monitor for mental status changes, fever, muscle rigidity and/or autonomic instability. May cause orthostatic hypotension, impaired core body temperature, significant wt gain and/or sedation. Monitor for behaviour changes or suicidal ideation. Patients with breast cancer or other prolactin-dependent tumors, renal impairment or at risk of seizures. May mask toxicity of other drugs or conditions e.g. intestinal obstruction, Reye's syndrome, brain tumor. Safety and efficacy have not been established in children <18 yr.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.