Panimun Bioral 100mg Cap 6s

Uses of Panimun Bioral 100mg Cap 6s

Ciclosporine is an immunosuppressant medicine and mostly used in patients who have undergone organ transplantation . Ciclosporine suppresses immune system and reduces chances of organ rejection by the body.Ciclosporine reduces the activity of the immune system by interfering with the activity and growth of T cells. For example in bone-marrow transplantation, kidney transplantation etc.

Side Effects of Panimun Bioral 100mg Cap 6s

Hypertension; hepatoxicity; tremor; paraesthesia, hypertrichosis, facial oedema, acne; gingival hypertrophy; hyperkalaemia, fluid retention; increased susceptibility to infections; GI symptoms. Potentially Fatal: Nephrotoxicity; convulsions.

Drug Interactions

Increased ciclosporin level by diltiazem, doxycycline, erythromycin, ketoconazole, methylprednisolone (high doses), nicardipine, verapamil, oral contraceptives. Drugs which reduce ciclosporin level are carbamazepine, isoniazid, phenobarbitone, phenytoin and rifampicin. Increased risk of convulsion when used concurrently with high-dose methylprednisolone. Potentially Fatal: Additive nephrotoxicity when used with aminoglycosides, amphotericin B, ciprofloxacin, colchicine, melphalan, co-trimoxazole and NSAIDs.

Contraindications

Hypersensitivity; malignant neoplasms; uncontrolled hypertension; psoriasis; lactation.

Mechanism of Action

Ciclosporin is a strong immunosuppressant that acts mainly on the helper T-cells. It inhibits the activation of calcineurin and production of interleukin-2, thus reducing cell-mediated immune response. Absorption: Incompletely and variably absorbed from the GI tract (oral). Distribution: Widely distributed; crosses the placenta and enters breast milk. Protein-binding: 90%. Metabolism: Hepatic: Extensive. Excretion: In faeces via the bile; 5-20 hr (elimination half-life), more rapid in children.

Special Precautions

Renal and hepatic impairment; hyperuricaemia; anaphylaxis; history of allergic reactions; pregnancy; monitor BP, serum electrolytes, renal and hepatic function.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.