Profasi-5000 IU Inj.

Uses of Profasi-5000 IU Inj.

Chorionic Gonadotrophin has actions similar to Luteinizing hormone (LH) and is used both in males and females for different purposes. In females, chorionic gonadotropin is used along with other medications like menotropins and urofollitropin to improve chances of conception.In males, LH and chorionic gonadotropin stimulate the testes to produce male hormones such as testosterone.

Side Effects of Profasi-5000 IU Inj.

Headache, irritability, restlessness, depression, fatigue, oedema; precocious puberty, gynaecomastia; pain at Inj site; enlargement of preexisting ovarian cysts and possible rupture; arterial thromboembolism; shock; abdominal pain. Potentially Fatal: Ovarian hyperstimulation syndrome (OHSS).

Contraindications

Hypersensitivity; precocious puberty, prostatic carcinoma or other androgenic dependent neoplasm. Pregnancy and lactation.

Mechanism of Action

Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone. Absorption: Peak concentrations after 6 hrs (IM). Distribution: Mainly in the gonads. Excretion: Via the urine (10-12% of IM dose within 24 hrs). Elimination half-life: 6-11 hrs (initial phase), 23-38 hrs (terminal phase).

Special Precautions

Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism. Patients with cardiac or renal disease, epilepsy, migraine or asthma.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.