Rantac-300 Tab 15s

Side Effects of Rantac-300 Tab 15s

Headache, dizziness. Rarely hepatitis, thrombocytopaenia, leucopaenia, hypersensitivity, confusion, gynaecomastia, impotence, somnolence, vertigo, hallucinations. Potentially Fatal: Anaphylaxis, hypersensitivity reactions.

Drug Interactions

Antacids may interfere with absorption. May decrease the GI absorption of ketoconazole. Smoking may decrease the plasma levels of ranitidine. May cause an increase in the bioavailability of furosemide.

Contraindications

Porphyria.

Mechanism of Action

Ranitidine blocks histamine H2-receptors in the stomach and prevents histamine-mediated gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated factor secretion or serum gastrin. Absorption: 50% with peak plasma concentrations after 2-3 hr (oral); rapid with peak plasma concentrations after 15 min (IM). Distribution: Widely distributed. Crosses the placental barrier and enters breast milk. Protein-binding: 20% Metabolism: Hepatic; converted to N-oxide, S-oxide and desmethylranitidine. Excretion: Urine (as unchanged drug) within 24 hr; faeces; 2-3 hr (elimination half-life).

Special Precautions

Exclude malignancy before treating gastric ulcer. Renal and hepatic impairment. Infants, pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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