Retune LS Tablet 10s

Side Effects of Retune LS Tablet 10s

Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido. Potentially Fatal: Neuroleptic malignant syndrome.

Drug Interactions

Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.

Contraindications

Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.

Mechanism of Action

Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent. Absorption: Oral bioavailability is about 30%; peak plasma concentrations after about 3 hr. Excretion: Mainly via urine. Plasma half-life: 9.7 hr (oral); 4.3 hr (IV).

Special Precautions

May impair ability to drive or operate machinery. Pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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