Temozol 250 Capsule 5s

Uses of Temozol 250 Capsule 5s

Temozolomide is an anti-cancer medicine and is used together with radiation therapy to treat certain types of brain tumor in adults.

Side Effects of Temozol 250 Capsule 5s

Common side effects of Temozolomide include :
1. Nausea & vomiting
2. Constipation, diarrhoea, abdominal pain, anorexia,
3. Headache and fatigue
4. Convulsions, dizziness, memory impairment, impaired concentration, tremors,
5. Blurred vision, hearing impairment, speech disorder, rash, infection, oral candidiasis,
6. Dyspnoea, coughing,
7. Neutropenia, thrombocytopenia, leucopenia, anaemia,
8. Hyperglycemia, decreased weight
9. Insomnia, anxiety, alopecia, muscle weakness, urinary incontinence, increased alanine aminotransferase. Rarely, myelodysplastic syndrome and secondary malignancies.

Drug Interactions

Reduced effectiveness of vaccines and generalised infection may occur in patients immunised with live vaccines. Decreased temozolomide clearance with valproic acid. Potentially Fatal: Increased risk of myelosupression with other myelosuppressive agents. Increased risk of myelosuppression with colony stimulating factors (e.g. filgrastim, molgramostim and lenograstim) if given at the same time, colony stimulating factors to be used 24 hr before or until 24 hr after chemotherapy.

Contraindications

Hypersensitivity to dacarbazine. Severe myelosupression. Pregnancy.

Mechanism of Action

Temozolomide, a triazene, is an inactive prodrug. It interferes with the growth and spread of cancer cells in the body in the body.

Special Precautions

Severe hepatic and renal impairment.
Elderly >70 yr or children.
Women of child bearing potential should avoid becoming pregnant during therapy. Males should be advised not to father a child up to 6 month after treatment and to consider cryoconservation of sperms due to possibility of irreversible infertility.
Unknown if distributed into breastmilk, discontinue nursing due to potential risk. May impair ability to drive or operate machinery.
Swallow capsules whole with a full glass of water on an empty stomach or at bedtime. Do not take a 2nd dose if capsules are vomited. Monitor CBC wkly during concomitant therapy and on day 22 of each 28 day treatment cycle, followed by weekly blood count until recovery. Hepatitis screening and prophylactic therapy with antiviral agents as clinically indicated to be considered. Prophylaxis for Pneumocystis jiroveci (or Pneumocystis carinii) pneumonia (PCP) needed for all patients receiving concomitant temozolomide and radiation therapy for the 42-day regimen; if patients experience lymphocytopenia during the concomitant phase of therapy, PCP prophylaxis should be continued until recovery from lymphocytopenia. Monitor closely for PCP development in all patients. Anti-emetic prophylaxis recommended.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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