Zoryl M 0.5mg Tablet 15s

Uses of Zoryl M 0.5mg Tablet 15s

1. The combination of glimepiride and metformin is indicated for treating type 2 diabetes mellitus.
2. It is used when diet, exercise, and metformin or sulfonylurea alone are insufficient for glycemic control.
3. This combination helps regulate blood sugar levels by enhancing the body's insulin response and reducing liver sugar production.

Side Effects of Zoryl M 0.5mg Tablet 15s

Diarrhea

Vomiting

Metallic taste

Rash

Isolated transaminase elevations

Cholestatic jaundice

1. Allergic skin reactions
2. Photosensitivity reactions
3. Leukopenia
4. Agranulocytosis
5. Thrombocytopenia
6. Hemolytic anemia
7. Aplastic anemia
8. Pancytopenia
9. Blurred vision

Potentially Fatal:

Lactic acidosis

Drug Interactions

Concomitant admin with propranolol increases Cmax, AUC, and T1/2 of glimepiride. Aspirin increases the mean AUC of glimepiride. Furosemide increases the Cmax of metformin. Potentially Fatal: NSAIDS, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, MAOs, and beta blockers potentiate the hypoglycemic action of glimepiride.

Contraindications

The combination is contraindicated in patients with:

1. Severe renal impairment (glomerular filtration rate [GFR] <30 mL/min/1.73 m²)
2. Metabolic acidosis, including diabetic ketoacidosis
3. Hypersensitivity to glimepiride, metformin, or any component of the medication

Mechanism of Action

1. Glimepiride: It is a sulfonylurea that stimulates insulin release from pancreatic beta cells, thereby lowering blood glucose levels.
2. Metformin: It is a biguanide that decreases hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Special Precautions

Renal and hepatic impairment. Avoid alcohol consumption. Hypoglycaemic episodes.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.