Abamune 300 mg Tablet 30s

Uses of Abamune 300 mg Tablet 30s

Abacavir is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body. Abacavir is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Abacavir is not a cure for HIV or AIDS.

Side Effects of Abamune 300 mg Tablet 30s

Anorexia, headache, nausea, vomiting, diarrhoea, rash, fever, cough, dyspnoea, fatigue, malaise, lethargy, abdominal pain. Pancreatitis and elevated blood glucose and TG concentrations. Potentially Fatal: Severe hypersensitivity reactions.

Drug Interactions

Alcohol may cause decreased elimination of abacavir. Lactic acidosis with nucleoside analogues concomitantly. Decreased serum concentrations of methadone.

Contraindications

Moderate to severe renal and hepatic impairment; end stage renal disease; history of hypersensitivity reactions. Pregnancy and lactation.

Mechanism of Action

Abacavir is converted to the active form carbovir triphosphate intracellularly. It competitively inhibits the reverse transcriptase of retroviruses interfering with HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication. Absorption: Rapidly absorbed after oral administration with an oral bioavailability of about 80%. Distribution: 50% bound to plasma proteins. Crosses the blood brain barrier. Metabolism: Undergoes intracellular metabolism to carbovir triphosphate which is the active metabolite. Excretion: Elimination half-life: About 1.5 hr after a single oral dose. Elimination by hepatic metabolism mainly by alcohol dehydrogenase and glucuronidation. The metabolites are excreted mainly in the urine.

Special Precautions

Renal or mild liver impairment; risk for liver impairment. Discontinued when hepatomegaly and unexplained metabolic acidosis develops, or liver function deteriorates. May impair ability to drive or engage in tasks requiring alertness. Discontinue treatment as soon as hypersensitivity is suspected.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.