Actifed DM Syrup

Side Effects of Actifed DM Syrup

Dizziness, GI disturbances.

Drug Interactions

Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol. Potentially Fatal: Memantine, moclobemide.

Contraindications

Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough.

Mechanism of Action

Dextromethorphan, a derivative of levorphanol, is an antitussive agent. It has a central action on the cough center in the medulla. Onset: Oral: 30 minutes. Duration: Oral: Up to 6 hr. Absorption: Rapidly absorbed in the GI tract. Metabolism: Hepatically metabolised. Excretion: Excreted in the urine unchanged.

Special Precautions

3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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