Actilyse 20mg Inj.

Uses of Actilyse 20mg Inj.

Alteplase is used to treat persons with heart attacks (acute myocardial infarctions), strokes, chest pain at rest (unstable angina), blood clots in the lungs (pulmonary thrombosis or embolism), and other less common conditions involving blood clots.

Side Effects of Actilyse 20mg Inj.

Vomiting, bleeding from puncture sites, gingival tissues and urinary tract. Potentially Fatal: Haemorrhage esp with previous trauma or unsuspected underlying cause of bleeding, intracerebral bleeding.

Drug Interactions

Heparin reduces risk of coronary reocclusion. Prostacyclin and nitrates increase plasma alteplase clearance. Potentially Fatal: Increased risk of GI bleeding with NSAIDs. Increased risk of hemorrhage with warfarin.

Contraindications

Recent surgery or trauma, susceptibility to internal bleeding, history of cerebrovascular accident, uncontrolled hypertension, esophageal varices, heavy vaginal bleeding, coagulation defects, aneurysm and poor glycaemic control.

Mechanism of Action

Alteplase initiates local fibrinolysis and dissolution of clots by binding to fibrin in a thrombus and the fibrin-bound plasminogen is converted to plasmin. Excretion: Cleared rapidly from the plasma mainly by hepatic metabolism. Half-life: 4-5 minutes (initial); about 40 minutes (terminal).

Special Precautions

Children, elderly. Pregnancy. Monitor intracranial haemorrhage and BP in acute stroke. Renal impairment.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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This content is for educational purposes only. Please consult your doctor before use.