Aggrenox Capsule

Uses of Aggrenox Capsule

Dipyridamole and Aspirin combination is used to reduce the chance of stroke , ischemia or other serious medical problems that may occur when a blood vessel is blocked by blood clots.Dipyridamole works by helping to prevent dangerous blood clots from forming.

Side Effects of Aggrenox Capsule

GI Disturbances, Headache, Dizziness, Faintness, Facial Flushing, Skin Rash, Liver Dysfunction, Angina. Large Doses May Lower BP. Potentially Fatal: Risk Of Worsening Angina And Cardiac Arrhythmias When Given IV.

Drug Interactions

Aminophylline May Reverse Vasodilatation Effect. Useful Combination With Aspirin In Prevention Of Thromboembolism. Efficacy Reduced By Concurrent Admin Of Antacids. Concurrent Use May Increase The Cardiotoxic Effects Of Adenosine. Potentially Fatal: Potentiates Effects Of Oral Anticoagulants And Antiarrhythmic Agents.

Contraindications

Hypersensitivity. Peptic Ulcer.

Mechanism of Action

Dipyridamole Causes An Accumulation Of Adenosine, Adenine Nucleotides And CAMP By Inhibiting The Activity Of Adenosine Deaminase And Phosphodiesterase Thus Inhibiting Platelet Aggregation And May Cause Vasodilation. Absorption: Absorbed Incompletely From The GIT (Oral); Peak Plasma Concentrations After 75 Min. Distribution: Protein-Binding: Highly Bound. Metabolism: Hepatic; There Is Enterohepatic Recirculation. Excretion: Via Bile (As Glucuronides); 10-12 Hrs (Elimination Half-Life).

Special Precautions

In Patients With Rapidly Worsening Angina, Subvalvular Aortic Stenosis, Haemodynamic Instability Associated With Recent MI Or Coagulation Disorders Esp When Given IV During Myocardial Imaging. Hypotension, Unstable Angina, Aortic Stenosis. Pregnancy And Lactation. Safety And Efficacy Are Not Established In Childn < 12 Yrs.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.