Brufen Junior Syrup

Side Effects of Brufen Junior Syrup

Oral: Dyspepsia, vomitting, abdominal pain, heart burn, nausea, diarrhoea, epigastric pain, edema, fluid retention, dizziness, rash, tinnitus. Parenteral: Intraventricular hemorrhage, skin irritation, hypocalcemia, hypoglycemia, GI disorders, anemia, apnea, respiratory infection, sepsis. Potentially Fatal: Severe CV thrombotic events. Severe GI bleeding, ulceration and perforation.

Drug Interactions

Reduces effects of antihypertensives. Enhanced effect with moclobemide. Increased risk of GI bleeding with warfarin. Potentially Fatal: Reduces antiplatelet effect of aspirin. Increases risk of methotrexate and lithium toxicity.

Contraindications

Active peptic ulcer; hypersensitivity. Neonates with congenital heart disease, suspected necrotising enterocolitis and active bleeding (parenteral).

Mechanism of Action

Ibuprofen exhibits anti-inflammatory, analgesic and antipyretic activities. Its analgesic effect is independent of anti-inflammatory activity and has both central and peripheral effects. It potently inhibits the enzyme cyclooxygenase resulting in the blockage of prostaglandin synthesis. It also prevents formation of thromboxane A2 by platelet aggregation. Onset: Analgesic: 30-60 min. Anti-inflammatory: ≤7 days. Duration: 4-6 hr. Absorption: Oral: Peak plasma concentrations after 1-2 hr. Topical: Minimal. Distribution: Protein-binding: 90-99%. Metabolism: Hepatic via oxidation. Excretion: Via urine (1% as free drug), some feces; 2 hr (plasma half-life).

Special Precautions

Asthma; renal or hepatic disorders; bleeding disorders; CV disease. Pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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