Ciplox TZ Tablet 10s

Side Effects of Ciplox TZ Tablet 10s

Nausea, headache, vomiting, fatigue, abdominal pain, depression, dyspepsia, constipation, dry mouth, sometimes diarrhea, metallic taste, urticaria, erythema & rashes; rarely convulsions & hematological changes. Potentially Fatal: Severe hypersensitivity reaction (rarely).

Drug Interactions

Antacids, sucralfate, calcium, Fe & Zn prep reduce absorption of ciprofloxacin. Concurrent use with ciclosporin may lead to transient increases in serum creatinine levels. Increases plasma levels and elimination half-life of theophylline; potentiates oral anticoagulant effects; disulfiram-like effect with alcohol. May affect metabolism of caffeine resulting in reduced clearance of caffeine.

Contraindications

Hypersensitivity, patients with a history of blood dyscrasias.

Mechanism of Action

Ciprofloxacin is bactericidal against enteropathogens like Shigella, Salmonella, E coli, C jejuni, Vibrio cholerae etc.It acts by inhibition of DNA synthesis. Tinidazole is a potent anaerobicide. It is also effective against Entameba & Giardia. It acts by damaging DNA strands. This combination has the advantage of being effective against both bacteria & protozoa. Entameba requires normal faecal flora for its survival; ciprofloxacin kills the pathogenic intestinal bacteria & alters intestinal flora, & tinidazole directly eradicates Entameba. This combination can also be used in other systemic infections caused by susceptible organisms.

Special Precautions

Renal impairment, history of seizures; ensure adequate hydration & urinary output; avoid alcohol ingestion. Not recommended for use in lactation and pregnancy. Not recommended for children. Patients with CNS disorders. Inadequate water intake during treatment may cause crystalluria.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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