Clome 25 mg Tablet

Side Effects of Clome 25 mg Tablet

Ovarian enlargement; abdominal pain and bloating; blurred vision; hot flushes; breast discomfort; depression; multiple or ectopic pregnancies; weight gain, nausea, vomiting; endometriosis; headache, convulsions, dizziness, fatigue, vertigo, insomnia; rash.

Drug Interactions

Decreased response with danazol.

Contraindications

Hypersensitivity; abnormal bleeding; pregnancy, lactation; liver dysfunction; uncontrolled thyroid or adrenal dysfunction, patient with an organic intracranial lesions such as pituitary tumor.

Mechanism of Action

Clomifene inhibits the negative feedback mechanisms of oestrogens in the hypothalamus and pituitary which stimulates the secretion of pituitary gonadotrophic hormones resulting in stimulation of ovulation. Absorption: Absorbed as citrate in the GI tract (oral). Metabolism: Hepatic; undergoes enterohepatic recycling. Excretion: Via the urine and bile; via the faeces (as unchanged drug and metabolites). 5-7 days (elimination half-life).

Special Precautions

Polycystic ovaries, evaluate presence of ovarian cyst before each cycle treatment. Uterine fibroids; visual disturbances may develop which will impair ability to drive or operate machinery.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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