Costini-1gm Tab

Side Effects of Costini-1gm Tab

Metallic taste, nausea, headache, vomiting, dark urine, flushing, anorexia, diarrhoea, tiredness, transient leucopenia. Potentially Fatal: Hypersensitivity.

Drug Interactions

Possible decrease in absorption with colestyramine. Possible increase in anticoagulant effect of warfarin. Monitor for toxicity if used with ciclosporin, tacrolimus or lithium.

Contraindications

Blood dyscrasias, organic neurologic disorders, hypersensitivity to 5-nitroimidazole derivatives, porphyria. Lactation, pregnancy (1st trimester).

Mechanism of Action

Tinidazole, a 5 nitroimidazole derivative with antimicrobial actions similar to metronidazole, is active against both protozoa (e.g.Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibit DNA synthesis in microorganism. Absorption: Almost completely absorbed from the GI tract (oral); peak plasma concentrations after 2 hr. Distribution: Widely distributed; breast milk, CSF, saliva, bile and body tissues (high concentrations similar to plasma), crosses the placenta. Protein-binding: 12%. Metabolism: Converted to an active hydroxy metabolite. Plasma elimination half-life: 12-14 hr. Excretion: Via urine (as unchanged drug and metabolites), via faeces (small amounts).

Special Precautions

Tinidazole, a 5 nitroimidazole derivative with antimicrobial actions similar to metronidazole, is active against both protozoa (e.g.Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibit DNA synthesis in microorganism. Absorption: Almost completely absorbed from the GI tract (oral); peak plasma concentrations after 2 hr. Distribution: Widely distributed; breast milk, CSF, saliva, bile and body tissues (high concentrations similar to plasma), crosses the placenta. Protein-binding: 12%. Metabolism: Converted to an active hydroxy metabolite. Plasma elimination half-life: 12-14 hr. Excretion: Via urine (as unchanged drug and metabolites), via faeces (small amounts).

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.