Doricrit 500 mg Injection

Side Effects of Doricrit 500 mg Injection

Headache, nausea, diarrhoea, rash, phlebitis, elevated hepatic enzymes, oral candidiasis, anaemia, vulvomycotic infection, renal impairment, neutropenia, leucopenia, thrombocytopenia. Potentially Fatal: Anaphylaxis, toxic epidermal necrolysis, Stevens-Johnson Syndrome, interstitial pneumonia, seizure.

Drug Interactions

May decrease valproic acid serum concentrations. Probenecid may increase serum levels of doripenem and concomitant use is not recommended.

Contraindications

Hypersensitivity; anaphylactic reactions to beta-lactams.

Mechanism of Action

Doripenem is a broad-spectrum carbapenem with potent in vitro antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria including Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins; which in turn inhibits the final transpeptidase step of peptidoglycan synthesis in bacterial cell walls. Absorption: Cmax and AUC are linear over a dose range of 0.5-1 g when given over 1 hr by IV infusion. Distribution: Average binding to plasma proteins: About 8.1%; independent of plasma drug concentrations. Median Vd: 16.8 L Metabolism: Primarily metabolised by dehydropeptidase-I to a microbiologically inactive ring-opened metabolite. Excretion: Primarily excreted in urine (about 70% as unchanged drug, about 15% as ring-opened metabolite); faeces (≤1%). Mean half-life elimination in healthy adults: About 1 hr.

Special Precautions

May decrease serum concentration of valproic acid to below therapeutic range thus increasing risk of breakthrough seizure; consider alternative antimicrobial agents or additional anti-seizure medications if concurrent usage is necessary. Prolonged use may result in Clostridium difficile-associated diarrhoea (CDAD). May cause development of drug-resistant bacteria when used in the absence of proven or strongly suspected bacterial infection. Renal impairment. Safety and efficacy have not been established in patients <18 yr old.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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