Fortum-500mg Injection

Uses of Fortum-500mg Injection

Ceftazidime is an anti-biotic and is used in teh treatment of bacterial infections. Ceftazidime is a potent anti biotic and is generally used in serious infections or life threatening infections due to gram positive bacteria.

Side Effects of Fortum-500mg Injection

Hypersensitivity, dizziness, diarrhoea, nausea, vomiting, renal impairment, rash, erythema multiforme, thrombocytopaenia, superinfection, phloebitis and thrombophloebitis at the site of injection. Potentially Fatal: Anaphylactic reactions, nephrotoxicity, pseudomembranous colitis.

Drug Interactions

Probenecid may decrease ceftazidime elimination time. Potentially Fatal: Furosemide and aminoglycosides may increase nephrotoxicity.

Contraindications

Hypersensitivity to cephalosporins.

Mechanism of Action

Ceftazidime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Peak plasma concentrations after 1 hr (IM), 5 min (IV bolus). Distribution: Widely distributed in body tissues and fluids; CSF (therapeutic concentrations when meninges are inflamed). Crosses the placenta and enters breast milk. Protein-binding: 10% Excretion: Mainly by the kidneys via the urine by glomerular filtration (80-90% as unchanged drug within 24 hr); passively excreted in bile but only a small proportion is eliminated. Clearance enhanced in cystic fibrosis; 2 hr (elimination half-life), prolonged in neonates and renal impairment.

Special Precautions

History of penicillin allergy; severe renal impairment; pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.