Hansepran 50 mg Capsule 10s

Side Effects of Hansepran 50 mg Capsule 10s

Red-brownish black discolouration of skin especially areas exposed to sunlight, hair, sweat, sputum, urine, faeces. Rash, pruritus, photosensitivity, diarrhoea, nausea, abdominal pain, vomiting, weight loss, headache, drowsiness, dizziness, taste disorders, dryness of the skin, ichthyosis, decreased tear and sweat production. Potentially Fatal: Crystal depletion in the wall of small bowel mesenteric lymph nodes, liver and spleen. Severe abdominal symptoms including bowel obstruction, GI bleeding and splenic infarction.

Drug Interactions

NA

Contraindications

Hypersensitivity. Lactation.

Mechanism of Action

Clofazamine inhibits mycobacterial growth by binding preferentially to mycobacterial DNA. It also has some anti-inflammatory activity. Absorption: About 45-70% of the dose is absorbed from the GI tract (oral); increased absorption when taken as microcrystalline formulations or after food. Distribution: Lipophilic; body tissues, reticuloendothelial cells, body organs and tissues; crosses the placenta and enters breast milk. Excretion: Via faeces (as unchanged), via urine (1% as unchanged drug and metabolites), sebaceous and sweat glands.

Special Precautions

Pregnancy. Patients with GI symptoms.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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