Limus 1mg Tab

Side Effects of Limus 1mg Tab

GI disturbances, tremor, acne, impaired renal function, hyperlipidaemia, peripheral oedema, headache, pain, asthenia and hypertension. Arthralgia, hypokalaemia, pyelonephritis, leucopenia, anaemia and angioedema. Potentially Fatal: Fatal hepatic necrosis.

Drug Interactions

Inhibitors of CYP3A4 such as ketoconazole and protease inhibitors may increase the plasma concentrations of sirolimus. Concurrent admin with ciclosporin may lead to changes in the rate and extent of sirolimus absorption thus the drugs should be taken at least 4 hr apart. Increased risk of calcineurin inhibitor-induced haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura or thrombotic microangiopathy when used with a calcineurin inhibitor. May lead to angioneurotic oedema-type reactions when used with ACE inhibitor. May decrease response to vaccines.

Contraindications

Pregnancy and lactation

Mechanism of Action

Sirolimus is a potent non-calcineurin inhibiting immunosuppressant used for renal transplantation. It inhibits T-lymphocyte activation and proliferation. It also inhibits antibody production. It has been shown to possess antifungal and antineoplastic properties. Absorption: Rapidly absorbed in the GI tract after oral admin. Distribution: Extensively bound to plasma proteins. Metabolism: Metabolised by CYP3A4 via demethylation or hydroxylation. Excretion: Mainly excreted via faeces; only about 2% excreted in the urine.

Special Precautions

Hepatic or renal impairment. Kidney function should be monitored. Avoid exposure to sun or ultraviolet light. May increase risk of infection and development of lymphoma. Use in lung or liver transplant patients is not recommended as the safety and efficacy of sirolimus in such patients have not been established.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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