Midacip Nasal Spray 5ml

Uses of Midacip Nasal Spray 5ml

Midazolam is used for conscious sedation before and during diagnostic or surgical procedures either in combination with or without local anesthesia. It may be used as a premedication before anesthesia, for inducing anesthesia, or as a sedative component of combined anesthesia. Midazolam may also be indicated for the treatment of prolonged, acute, convulsive seizures (fits) in infants, toddlers, children and adolescents

Side Effects of Midacip Nasal Spray 5ml

Physical And Psychological Dependence With Withdrawal Symptoms; Decreased Tidal Volume And Respiration Rate; Apnoea; Headache; Hiccup; Nausea, Increased Appetite, Vomiting; Cough; Oversedation; Seizure-Like Activity (Paediatrics); Paradoxical Reactions; Kernicterus; Nystagmus; Skin Rash, Pruritus; Reduced Alertness, Confusion, Euphoria, Hallucinations, Fatigue, Dizziness, Ataxia, Post-Operative Sedation, Anterograde Amnesia; Jaundice; Cardiac Arrest, Heart Rate Changes, Thrombosis; Anaphylaxis; Laryngospasm, Bronchospasm. Potentially Fatal: Respiratory Depression, Respiratory Arrest; Hypotension.

Drug Interactions

Increased CNS Depression With Alcohol, Opioids, Barbiturates, Other Sedatives And Anaesthetics. Increased Respiratory Depression With Opiates, Phenobarbital, Other Benzodiazepines. Plasma Concentrations Increased By CYP3A4 Inhibitors Such As Cimetidine, Erythromycin, Clarithromycin, Diltiazem, Verapamil, Ketoconazole And Itraconazole, Antiretroviral Agents, Quinupristin With Dalfopristin. Midazolam Concentration Decreased By Phenytoin, Carbamazepine, Phenobarbital, Rifampicin. Halothane, Thiopental Requirements May Be Reduced During Concurrent Use.

Contraindications

Acute Narrow-Angle Glaucoma; Coma Or Patients In Shock; Acute Alcohol Intoxication; Intrathecal And Epidural Admin. Acute Pulmonary Insufficiency Or Marked Neuromuscular Respiratory Weakness Including Unstable Myasthenia Gravis; Severe Respiratory Depression.

Mechanism of Action

Midazolam Is A Short-Acting Benzodiazepine. It Exerts Sedative And Hypnotic, Muscle Relaxant, Anxiolytic And Anticonvulsant Actions. While The Probable Anxiolytic Action Might Be As A Result Of The Drug's Ability To Increase Glycine Inhibitory Neurotransmitter Level, The Hypnotic/Anaesthetic Action May Be Due To The Occupation Of The Benzodiazepine And GABA Receptors Leading To Membrane Hyperpolarisation And Neuronal Inhibition, And Further Interfering With The Re-Uptake Of GABA At The Synapses. Absorption: Rapidly Absorbed (Any Route); Peak Plasma Concentrations After 20-60 Min (Depending On Route). Distribution: Crosses The Placenta; Enters Breast Milk. Protein-Binding: 96% Metabolism: Extensively Hepatic Via CYP3A4 Isoenzyme; Converted To Hydroxymethylmidazolam. Excretion: Urine (As Glucuronide Conjugates); 2 Hr (Elimination Half-Life), Prolonged In Neonates, Elderly And Hepatic Impairment.

Special Precautions

Paediatric Patients With Cardiovascular Instability; Chronic Renal Failure; Open-Angle Glaucoma; Cardiac Disease; Respiratory Disease; Myasthenia Gravis; Neonates; History Of Drug Or Alcohol Abuse; Elderly And Debilitated (Reduce Dose); Avoid Prolonged Use Or Abrupt Withdrawal; Hepatic Impairment; Severe Fluid Or Electrolyte Disturbances. May Impair Ability To Drive Or Operate Machinery; Titrate Dose Carefully; Monitor For Early Signs Of Hypoventilation, Airway Obstruction, Or Apnea. Pregnancy, Lactation

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.