Modatec 200 mg Tablet 10s

Uses of Modatec 200 mg Tablet 10s

Modafinil is an analeptic drug, prescribed for narcolepsy, obstructive sleep apnea and shift work disorder. It works by altering neurotransmitters in the brain.

Side Effects of Modatec 200 mg Tablet 10s

Headache, nervousness, insomnia, agitation, confusion, personality disorders, tremor, anxiety; GI disturbances; hypertension, palpitations, tachycardia; angioedema; psychosis, depression, mania, abnormal LFTs. Potentially Fatal: Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis.

Drug Interactions

May increase metabolism of ciclosporin, oral contraceptives. May increase the levels/effects of warfarin, TCAs and CYP2C19 substrates (e.g. citalopram, diazepam, methsuximide, phenytoin, propranolol, sertraline). Levels/effects may be reduced with CYP3A4 inducers (e.g. aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, rifamycins). Levels/effects may be increased with CYP3A4 inhibitors (e.g. azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin, verapamil). Avoid alcohol.

Contraindications

Uncontrolled moderate to severe hypertension or cardiac arrhythmias; history of left ventricular hypertrophy or ischaemic ECG changes, chest pain, any clinical signs of mitral valve prolapse.

Mechanism of Action

The mechanism of modafinil is unknown but it appears to exert its stimulant effects by reducing GABA-mediated neurotransmission. Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 2-4 hr. Distribution: Protein-binding: Approx 60% (mainly to albumin). Metabolism: Hepatic; partially by CYP3A4 and CYP3A5 isoenzymes. 2 major metabolites: Acid modafinil and modafinil sulfone (both inactive). Excretion: Mainly via urine (<10% of the dose eliminated unchanged). Elimination half-life: 15 hr (after multiple doses).

Special Precautions

History of psychosis, depression, mania. Discontinue use if there is any sign of rash or hypersensitivity reaction. Increase monitoring in patients with hypertension. Hepatic and renal impairment. Tourette's syndrome. May impair ability to drive or operate machinery. Pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.