Neo Mercazole 5mg Tab 100s

Uses of Neo Mercazole 5mg Tab 100s

Carbimazole is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole.

Side Effects of Neo Mercazole 5mg Tab 100s

Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia. Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre.

Drug Interactions

Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid.

Contraindications

Hyperthyroidism due to nodular goitre.

Mechanism of Action

Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase. Absorption: Rapid from the GIT (oral); peak plasma concentrations after 1-2 hrs. Distribution: High concentrations in the thyroid gland; crosses the placenta; enters breast milk. Metabolism: Hepatic; converted to methimazole. Excretion: Urine (<12% unchanged drug); 3-6 hrs (elimination half-life).

Special Precautions

Liver diseases, pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.