Neosporin Powder 10g

Side Effects of Neosporin Powder 10g

Dizziness, paraesthesia, muscle weakness, ataxia, confusion, drowsiness, psychoses, convulsions, coma. Neuromuscular blockade characterized by respiratory paralysis and apoea. Acute interstitial nephritis; nausea, vomiting, electrolyte imbalance. Topical: Hypersensitivity eg, macular rashes, risk of systemic toxicity if applied to large areas of broken skin. Otic: Ototoxicity, stinging and burning sensation. Ophthalmic: Hypersensitivity, itching, redness and oedema of conjunctiva and eye lid. Intrathecal: Meningeal irritation. Potentially Fatal: Nephrotoxicity (higher doses and preexisting failure), neurotoxicity; resp failure; anaphylaxis.

Drug Interactions

May enhance action of neuromuscular blockers. Increased risk of ototoxicity and nephrotoxicity when used with vancomycin. Potentially Fatal: Potentiates nephrotoxicity produced by cefalotin and aminoglycosides.

Contraindications

Hypersensitivity, perforated ear drums.

Mechanism of Action

Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids. Absorption: Minimal from GIT except in neonates. Peak plasma concentrations after 2 hr (IM). Distribution: Widely distributed; extensively bound to cell membranes in the tissues. Excretion: Excreted mainly by kidneys. Urine (>60% as unchanged drug); 6 hr (elimination half-life).

Special Precautions

Application to large areas of broken skin. Renal impairment; monitor renal function. Pregnancy, lactation. Monitor serum concentrations of polymyxins in patients receiving parenteral therapy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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