Phexin 250mg Capsule 10s

Side Effects of Phexin 250mg Capsule 10s

Pain at inj site; hypersensitivity; GI disturbances; eosinophilia, neutropenia, leucopenia, thrombocytopenia. Potentially Fatal: Anaphylactic reactions; nephrotoxicity.

Drug Interactions

Probenecid produces higher and prolonged serum levels. Potentially Fatal: Increased nephrotoxicity with aminoglycosides and furosemide.

Contraindications

Hypersensitivity to cephalosporins.

Mechanism of Action

Cefalexin binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Almost completely absorbed from the GI tract with peak plasma concentrations after 1 hr (oral); may be delayed if taken with food. Distribution: Widely distributed but does not penetrate the CSF; bile (therapeutic concentrations). Crosses the placenta and enters the breast milk (small amounts). Protein-binding: Up to 15% Metabolism: Not metabolised. Excretion: Via the urine within 6 hr by glomerular filtration and renal tubular secretion (>80% as unchanged); via the bile. May be removed by haemodialysis and peritoneal dialysis; 1 hr (elimination half-life).

Special Precautions

Hypersensitivity to penicillins; pseudomembranous colitis; renal failure; pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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