Synclar 250 mg Tablet 4s

Uses of Synclar 250 mg Tablet 4s

Clarithromycin is a macrolide antibiotic. Clarithromycin is used to treat respiratory tract infections and skin infections.

Side Effects of Synclar 250 mg Tablet 4s

GI upset, glossitis, stomatitis, altered taste; headache, dizziness, hallucinations, insomnia, other CNS effects; rash; hepatic dysfunction, Potentially Fatal: Pseudomembranous colitis, anaphylaxis, Stevens-Johnson syndrome.

Drug Interactions

May potentiate oral anticoagulant action. May elevate serum digoxin concentration. Potentially Fatal: Increases plasma concentrations of terfenadine or astemizole. Increases the risk of ventricular arrhythmias in patients with preexisting cardiac diseases.

Contraindications

Hypersensitivity. Patients receiving terfenadine, astemizole, pimozide, cisapride and ergot derivatives. Pregnancy; history of acute porphyria.

Mechanism of Action

Clarithromycin inhibits protein synthesis by binding to 50s ribosomal subunits of susceptible organisms. It has activity against susceptible streptococci and staphylococci as well as other species including B. catarrhalis, L. spp, C. trachomatis and U. urealyticum. Absorption: Rapidly absorbed from the GI tract (oral). Distribution: Widely distributed (concentrations exceed those in serum); enters the breast milk. Metabolism: Hepatic (extensive); converted to 14-hydroxyclarithromycin and other metabolites. Excretion: Via the bile into the faeces; via the urine (20-30% as unchanged, 10-15% as 14-hydroxyclarithromycin and other metabolites).3-4 hr and 5-7 hr (elimination half-life)

Special Precautions

Renal and hepatic impairment; macrolide cross-resistance; lactation, children.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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