Ticocin 200 mg Injection

Uses of Ticocin 200 mg Injection

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis.

Side Effects of Ticocin 200 mg Injection

Fever, chills, allergic reactions, GI disturbances, headache, dizziness, "red-man" syndrome, disturbances in liver enzymes, renal impairment, ototoxicity, blood dyscrasias. Pain, erythema, thrombophloebitis, abscess at site of admin. Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.

Drug Interactions

Other nephrotoxic and/or neurotoxic drugs.

Contraindications

Hypersensitivity.

Mechanism of Action

Glycopeptide antibiotic with spectrum of activity is similar to vancomycin but teicoplanin may be more active in vitro against enterococci and some anaerobic organisms but some coagulase-negative Staphylococci are less sensitive to teicoplanin than to vancomycin. Absorption: Poorly absorbed from the GI tract. IM bioavailability: 90%. Peak plasma concentrations: 1 hr (IV); 2-4 hr (IM). Distribution: Protein binding: 90-95%. Poor penetration into the CSF. It is taken up into white blood cells. Excretion: Excreted unchanged via urine (97%).

Special Precautions

Preexisting renal insufficiency, hypersensitivity to vancomycin. Perform periodic haematological studies, renal, LFT. Pregnancy, lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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