Zyloric 100mg Tablet 10s

Uses of Zyloric 100mg Tablet 10s

Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.

Side Effects of Zyloric 100mg Tablet 10s

Rash; alopoecia; GI disorders, taste disturbances, nausea, vomiting, abdominal pain, diarrhoea; paraesthesia, peripheral neuropathy, vertigo, headache, hepatic necrosis, drowsiness, neuritis, arthralgia; hypertension. Potentially Fatal: Stevens-Jonhson and/or Lyell's Syndrome (urticaria, fever, lymphadenopathy, arthralgia). Occasionally, thrombocytopaenia, agranulocytosis and aplastic anaemia.

Drug Interactions

Increased risk of skin rash when used with ampicillin or amoxicillin. May prolong half-life of chlorpropamide and dicumarol. May increase serum levels of ciclosporin. May increase bone marrow depression when used with cyclophosphamide Potentially Fatal: Increased haematological effects of azathioprine and mercaptopurine when co-administered with allopurinol.

Contraindications

Hypersensitivity; acute attack of gout.

Mechanism of Action

Allopurinol is an inhibitor of the enzyme xanthine oxidase which converts hypoxanthine to xanthine then uric acid. The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid, there is no risk of nephrolithiasis. Absorption: 90% of the dose is absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hrs. Distribution: Enters breast milk. Protein-binding: None. Metabolism: Converted to oxipurinol (alloxanthine). Excretion: Urine (as unchanged drug and metabolite), faeces. Elimination half-life: 1-2 hr (allopurinol), 15 hr (oxipurinol).

Special Precautions

Ensure adequate fluid intake. Prophylactically with an anti-inflammatory or colchicine for at least 1 mth. Withdraw immediately when sensitivity (skin rash, etc) appears. Pregnancy, lactation. Hepatic and renal impairment.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.