Bondronat 6mg/6ml Injection

Uses of Bondronat 6mg/6ml Injection

Ibandronic Acid used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. It may also be used to treat hypercalcemia (elevated blood calcium levels).

Side Effects of Bondronat 6mg/6ml Injection

Fever; influenza-like syndrome; electrolyte disturbances; GI disturbances; musculoskeletal pain; headache; rash, allergic dermatitis; anaemia; decreased alkaline phosphatase; hypercholesterolaemia; UTI; local reactions (parenteral); renal impairment (parenteral).

Drug Interactions

Impaired absorption with aluminium, calcium, iron, magnesium compounds. Increased risk of GI or renal adverse effects with NSAIDs. Additive hypocalcaemic effects with aminoglycosides.

Contraindications

Severe renal impairment, uncorrected hypocalcaemia, acute upper GI inflammation, inability to stand or sit upright for at least 60 min (oral).

Mechanism of Action

Ibandronic acid is a potent bone resorption inhibitor, which acts on osteoclasts or on osteoclast precursors. It increases bone mineral density by reducing the rate of bone resorption. Absorption: Poorly absorbed orally. Absolute bioavailability: <1%. Distribution: Protein-binding: 85-99%. Excretion: Via urine. Unabsorbed drug via faeces.

Special Precautions

History of bone/joint/muscle pain; dysphagia, oesophageal disease, gastritis, duodenitis, ulcers. Risk factors for osteonecrosis of the jaw. Pregnancy and lactation.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

Content Disclaimer

This content is for educational purposes only. Please consult your doctor before use.