Azactam 1gm Inj.

Uses of Azactam 1gm Inj.

Antibiotic

Side Effects of Azactam 1gm Inj.

IV: Phloebitis and thrombophloebitis. IM: Pain and swelling at inj site; diarrhoea, nausea, vomiting, altered taste; jaundice, hepatitis, high liver enzymes; long prothrombin time, partial thromboplastin time; rash, urticaria, eosinophilia. Potentially Fatal: Thrombocytopenia, neutropenia; overgrowth of susceptible organisms; pseudomembranous colitis.

Drug Interactions

Concurrent use with oral anticoagulants may increase prothrombin time.

Contraindications

Hypersensitivity; lactation.

Mechanism of Action

Aztreonam exhibits bactericidal action by inhibiting bacterial cell wall synthesis due to its high affinity for penicillin-binding protein 3 (PBP-3) of gram-negative bacteria. It is highly resistant to hydrolysis by β-lactamases. It is active against Enterobacteriaceae spp, E. coli, Klebsiella, Proteus, Providencia, Salmonella, Serratia, Shigella and Yersinia spp.. Absorption: Absorbed poorly from the GI tract (oral). Distribution: Body tissues and fluids (wide), bile, CSF (especially in the presence of meningitis), crosses the placenta and enters breast milk. Protein-binding: 56%. Metabolism: Minimal metabolism; SQ-26992 (primary metabolite, inactive). Excretion: Via urine by renal tubular secretion and glomerular filtration (60-70% as unchanged), via faeces (small amounts of unchanged drug and metabolites); 1.7 hr (elimination half-life). Removed by dialysis and peritoneal dialysis (lesser extent).

Special Precautions

Hypersensitivity to other β-lactams; renal and hepatic impairment; pregnancy.

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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