Bydureon Inj.

Side Effects of Bydureon Inj.

Hypoglycaemia, headache, nervousness, dizziness, weakness, feeling jittery, dose-dependent mild to moderate nausea, vomiting, decreased appetite, increased wt loss, asthenia, diarrhoea, abdominal distension and pain, dyspepsia, constipation, hyperhidrosis, GERD; mild inj site reactions; rash, hypersensitivity reactions, alopecia. Potentially Fatal: Acute pancreatitis, including fatal and non-fatal haemorrhagic or necrotising pancreatitis.

Drug Interactions

May reduce rate and extent of absorption of oral contraceptives and antibiotics, take these drugs at least 1 hr before exenatide. Concomitant use of oral hypoglycaemic (e.g. sulfonylureas) and other glucose-dependent insulin secretagogues (e.g. meglitinides) may increase risk of hypoglycaemia. May enhance anticoagulant effect of warfarin.

Contraindications

Exenatide is not a substitute for insulin. Patients w/ type 1 DM or diabetic ketoacidosis. End-stage renal disease; severe renal impairment (CrCl <30 mL/min).

Mechanism of Action

Exenatide is an incretin mimic that acts as an agonist at glucagon-like peptide 1 (GLP-1) receptor. It increases glucose-dependent insulin secretion by the pancreatic β-cells, suppresses inappropriately elevated glucagon secretion, increases β-cell growth/replication, and slows gastric emptying. It also decreases food intake by reducing appetite and increasing satiety. Absorption: Time to peak plasma concentration: Approx: 2 hr. Distribution: Volume of distribution: 28.3 L. Metabolism: Minimal systemic metabolism. Excretion: Via urine (majority of dose). Primarily eliminated by glomerular filtration w/ subsequent proteolytic degradation. Terminal half-life: Approx 2.4 hr.

Special Precautions

Moderate renal impairment (CrCl 30-50 mL/min) or renal transplantation; severe GI disease; history of alcoholism. Pregnancy and lactation. Monitoring Parameters Monitor for signs and symptoms of acute pancreatitis (e.g. persistent severe abdominal pain that may radiate to the back, nausea, vomiting, increased amylase or lipase levels).

How to Use

Take orally with food and water, as directed by your physician.

How to Store

Keep in a cool, dry place away from sunlight and moisture.

Safety Concerns

• Alcohol: Avoid during treatment.
• Breastfeeding: Not recommended.
• Pregnancy: Contraindicated.
• Liver/Kidney: Use with caution.

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